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Conversely, chronic NAD+ depletion during aging can impair both PARP-mediated DNA repair and sirtuin-mediated stress resistance, contributing to accelerated aging phenotypes
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17 By the enzymatic assay, normal values varies among laboratories with a lower limit of detection ranging between 0.15 and 0.2 g/L and lower value may be seen in approximately 20% of heterozygotes
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