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subjects who receive rAAV9.IDUA also receive an IS regimen consisting of corticosteroids (methylprednisolone 10 mg/kg IV once on Day 1 predose and oral prednisone starting at 0.5 mg/kg/day on Day 2 with gradual tapering and discontinuation by Week 12), tacrolimus (1.0 mg twice daily PO Day 2 to Week 24) with target blood level of 4 to 8 ng/mL and tapering over 8 weeks between Week 24 and 32, and sirolimus (a loading dose of 1 mg/m 2 every 4 hours ⁇ 3 doses on Day ⁇ 2 and then from Day ⁇ 1: sirolimus 0.5 mg/m 2 /day divided in twice a day dosing with target blood level of 4 to 8 ng/ml until Week 48)