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The significance of differences in protein abundance was determined with a Paired T-test for sibling cohort comparisons and a T-test for comparisons of unrelated groups such as Stage 1 versus Stage 3
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Although mTORC1 is the primary complex that responds to amino acid availability, reintroducing amino acids to cells deprived of both serum and amino acids increases the phosphorylation of AKT by mTORC2 146 (Fig
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