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9 Upon cell lysis, intracellular contents are released into the mAb-containing culture fluid, and it has been shown that thioredoxin and thioredoxin reductase enzymes act in the presence of nicotinamide adenine dinucleotide phosphate (NADPH) to reduce the antibody disulfides

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At the computational level, the structural differences between the enzyme-inhibitor binding sites of hTYR and mTYR were revealed