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Symptoms often appear gradually and can be mistaken for other conditions: Persistent fatigue that does not respond to sleep Weakness, especially feeling like you cannot keep up physically Pale or yellowish skin Brain fog and difficulty concentrating Forgetfulness Mood changes including irritability and depression Numbness or tingling in hands and feet Balance problems Smooth, sore tongue Constipation Rapid heartbeat or shortness of breath If you have these symptoms, see a doctor
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Concentrations of 1,8-diMQ and 5-amino-1MQ ranging from 10 nM to 200 or 600 µM, respectively, did not inhibit DNMT1 or PRMT3 (Figures 4A and 4B)
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