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KARs, however, have received less attention, despite their significant role in neuronal development, synaptic depolarization, intrinsic cellular excitability, and homeostatic synaptic plasticity gatekeeping (Valbuena and Lerma, 2021)

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Various dietary interventions, including carbohydrate, fat and, more recently, amino acid restriction, have been explored to combat this epidemic 3,4,5,6