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Sirtuins, poly(ADP-ribose) polymerases and the CD38/CD157 ectoenzymes cleave the glycosidic bond between the nicotinamide and the ADP-ribosyl moiety, releasing nicotinamide stoichiometrically, so NAD+ is destroyed rather than recycled and must be resynthesised through the NAMPT-limited salvage pathway (Cantó, Menzies and Auwerx, Cell Metabolism, 2015)

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When the fat cell membrane ruptures, the contents (primarily triglycerides) are released into the interstitial space between cells