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Theoretical considerations suggest fat loss effects should continue as long as the compound is administered, since the mechanism (beta-3 adrenergic lipolysis, lipogenesis inhibition) does not involve receptor desensitization in the way that some hormonal pathways do

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MET-097i vs Semaglutide: Ultra-Long-Acting vs Established GLP-1 Comparison Evidence-based comparison of MET-097i (ultra-long-acting once-monthly GLP-1 agonist) and semaglutide (established once-weekly/daily GLP-1 agonist) for weight loss and obesity treatment