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Overall, vulva-derived organoids hold promise for understanding epithelial biology, microbiome interactions, and diseases like genital infections and vulvar cancers ( 3.2.2 Vaginal organoids Research on vaginal development, primarily conducted in mice, has highlighted the intricate interplay between epithelial cells and the underlying stroma, influence of hormone receptor genes, and pivotal role of the Wnt/β-catenin pathway ( in vitro ( 3.2.3 Cervix organoids The cervix, which is vulnerable to human papillomavirus -induced cancer, lacks accurate modeling in 2D cultures
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