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In another study, DCA administration rescued locomotor deficits and elevated PDH activity in mice with ME/CFS-like manifestations induced by a 25-day repeated forced swimming test [145]

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(2011) found no difference in the extent of ME-induced MOR endocytosis in locus coeruleus neurons from animals chronically treated with morphine, but there was a decrease in the extent of reinsertion of receptors into the plasma membrane