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These analogs can be configured to pass the blood-brain barrier and target relevant receptor proteins in specific brain structures or they can be applied topically to the eye to discourage increases in intraocular pressure, decreased retinal microvascular blood flow, tissue inflammation and oxidative stress as well as the accumulation of extracellular material (drusen) that can disrupt normal vision
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Low serotonin levels can result in sadness, lack of motivation, or even depressive symptoms
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![Quantitative Importance of the Pentose Phosphate Pathway Determined by Incorporation of 13C from [2-13C]- and [3-13C]Glucose into TCA Cycle Intermediates and Neurotransmitter Amino Acids in Functionally Intact Neurons](https://journals.sagepub.com/cms/10.1038/jcbfm.2012.85/asset/6fbcf244-05cf-4f3d-afd9-6b813d751886/assets/images/large/10.1038_jcbfm.2012.85-fig1.jpg)
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