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However, the β 2 class of receptor can switch from G s to G i/o signaling following phosphorylation of the receptor by PKA

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“But surprisingly, when we removed the adrenal gland from the mice so that they couldn’t produce cortisol-like hormones, their hair still turned gray under stress.” After eliminating different possibilities, researchers honed in on the sympathetic nerve system, which is responsible for the body’s fight-or-flight response