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However, despite all these differences there is still a biological plausibility of a link between B 12 and depression given that B 12 is a necessary co-factor for methionine synthesis which provides methionine, the precursor of S-adenosylmethionine that is then needed for the formation of important brain neurotransmitters such as dopamine and norepinephrine (Reference Bailey, Stover and McNulty18,Reference Bottiglieri and Reynolds19)

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Key finding: Established pharmacokinetic data showing parenteral administration achieves rapid tissue-level increases, supporting injectable delivery