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Similar content being viewed by others Subjects Main The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE-II) clinical trial in healthy adults demonstrated that a simple 14% reduction of calories for 2 years without specific dietary prescription to alter macronutrient intake or meal timings can reprogramme the immunometabolic axis to promote healthspan 1,2,3

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Shimoda et al., 2017