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69,70 Concurrently, the Wnt/β-catenin pathway contributes to self-renewal via TCF/LEF-mediated transcription of stemness-related genes, although excessive activation of this pathway can cause aberrant proliferation

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Further clinical trials examining the use of SST in CRC using a personalized approach, combining SSTAs with other agents and possible new analogs targeting a wide variety of SSTRs, could provide exciting information and a new direction in CRC treatment [164]