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This review highlights that Metformin lowers blood glucose primarily by suppressing hepatic gluconeogenesis via mitochondrial and AMPK-related pathways, while also exerting anti-inflammatory effects by modulating NF-κB signaling

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Tamoxifen was applied after inducing obesity in male adiponectin-CreERT2 x p53-lox/lox (KO) mice or in control mice with p53-lox/lox lacking the Cre allele