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Graphical abstract created in This study is supported by a NIGMS-funded Pharmacology Training Program (T32 144303) to A.S

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This observation was especially significant with chloroquine treatment as monotherapy and the combination of sertraline and chloroquine in 1919 PSPH amp and PSPH V116I cell models, leading to a disrupted mitochondrial morphology, which appeared swollen and fragmented compared to healthy mitochondria (Fig