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However, we know that the first crucial biochemical step in a haemolytic episode is decrease of NADPH (Gaetani et al , 1979) and the consequent depletion of glutathione (GSH) through its conversion to glutathione disulfide (GSSG) (Beutler, 1957)

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In contrast, bright light exposure during the daytime, particularly in the early part of the day, reinforces circadian entrainment and improves subsequent sleep quality