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In vivo and in vitro cellular studies suggest that thiamine deficiency increases the production of reactive oxygen species (ROS), generating oxidative stress in the brain and neuronal tissues [55,56,57]
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![Quantitative Importance of the Pentose Phosphate Pathway Determined by Incorporation of 13C from [2-13C]- and [3-13C]Glucose into TCA Cycle Intermediates and Neurotransmitter Amino Acids in Functionally Intact Neurons](https://journals.sagepub.com/cms/10.1038/jcbfm.2012.85/asset/6fbcf244-05cf-4f3d-afd9-6b813d751886/assets/images/large/10.1038_jcbfm.2012.85-fig1.jpg)
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