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elevated intracellular GSH in cancer cells has been associated with resistance to chemotherapy, and supplementation during active cancer treatment should only occur under oncology guidance Renal impairment — high-dose IV glutathione has been associated with renal toxicity in the dermatology literature Concurrent use of medications whose efficacy depends on cellular oxidative stress — certain chemotherapy agents and some antimicrobial drugs rely on ROS-generating mechanisms

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, CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells