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Newly synthesized Nrf2 then accumulates and translocates to the nucleus, where it binds to antioxidant response elements (AREs) to drive the transcription of cytoprotective genes, including SLC7A11 (which drives cystine import) as well as glutamate-cysteine ligase and glutathione synthetase, which collectively orchestrate the de novo synthesis of GSH [68-70]