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What to expect: Maximum improvement in sleep architecture and sleep quality Strongest circadian rhythm reinforcement — the distinction between deep nighttime sleep and alert daytime wakefulness is maximized Full HPA axis modulation effects Optimal physical recovery and daytime energy The narcolepsy case study by Schneider-Helmert showed that DSIP's effects on sleep-wake rhythmicity were most pronounced with sustained treatment — compressing the sleep period while enhancing sleep quality within it, and reducing daytime sleep intrusions (Schneider-Helmert, 1984)

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Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model