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CYP2D6 CYP2D6 appears to be responsible for the formation of the metabolite 2-hydroxyolanzapine in vitro.113 Callaghan and associates111 found that concomitant treatment with the CYP2D6 inhibitor fluoxetine resulted in statistically significant but “clinically insignificant” changes in the serum levels and rates of clearance of olanzapine
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