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Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1

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Although most studies had described the beneficial effects of curcumin in PD, a few contradictory reports had shown that curcumin actually exacerbated the disease, notably in a study by Ortiz-Ortiz et al ., [380] which showed higher apoptosis rate in N27 mesencephalic cells after co-incubation in curcumin and paraquat