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In this systematic review, Pratama and colleagues highlight the paucity of studies specifically in those with metformin-induced B12 deficiency and the lack of guidance on best approaches to supplementation for treatment or prevention

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Patients with stage 2 or higher pressure injuries and malnutrition risk or malnutrition ∙ Energy: 30–35 kcal/kg/day ∙ Protein: 1.25–1.5 g/kg/day ∙ Water: 30 mL/kg or 1 mL/kcal ∙ If nutritional requirements cannot be met through meals, offer high-calorie, high-protein nutritional supplements in addition to the usual diet for adults