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Guideline proposals advocate mandated demographic reporting and enrolment targets tied to disease prevalence, yet few sponsors incorporate these metrics into study milestones or funding contingencies [353,355,360]

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To better understand how changes in intracellular GSH metabolism might contribute to the expansion, survival, and function of CD8 + T cells upon “chronic” antigenic stimulation, we used an in vitro system (26) whereby activated transgenic or wild-type (WT) T cells were expanded in the presence of persistent antigenic stimulation with either specific antigen (OVA-I/gp100) or anti-CD3–mediated stimulation and anti-CD28 costimulation for 7 days