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It has been shown that microglia exposed to LPS displayed a primed phenotype with heightened levels of inflammatory markers such as iNOS, IL-1β, and p65, which were accompanied by iron deposits and ferroptosis (41)
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ROS and RNS may trigger programmed cell death, e.g., apoptosis [29], necessary for tissue remodeling during the development and normal tissue turnover [30], proliferation, differentiation, maturation of neural stem cells, dendritic processes, and synaptic plasticity [31,32,33]