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Gut–Brain Axis-Related Disorders In disorders associated with the gut–brain axis, including PD, spinal cord injury, and depression, the ENS may function either as a locus for the initiation of pathological processes (such as the abnormal aggregation of α-synuclein in PD) or as a peripheral effector in response to central nervous system injury (such as intestinal dysmotility following spinal cord injury)
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