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Participants underwent continuous VIP infusion at 400 pmol/kg/hour for 100 minutes, resulting in: Sustained vasodilation, with reductions in: Total peripheral resistance by 30% Mean arterial pressure by 12% Forearm vascular resistance by 65% Increased cardiovascular output, including heart rate, and left ventricular contractility More clinical studies are needed to determine whether this can be used in pathologies of heart failure to improve cardiovascular outcomes