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Ferroptosis can be triggered by GSH depletion, which can be achieved by inhibiting GSH biosynthesis (e.g., buthionine sulfoximine (BSO) inhibits γ-glutamylcysteine synthetas (γ-GCS)) or blocking the uptake of cysteine from the extracellular environment (e.g., erastin inhibits the Xc − system) [126, 127]
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