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In 2025, more than 40 state attorneys general formally letter FDA about products with unknown contaminants and online sales of “research use only” GLP-1 active ingredients sold without prescriptions
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Specifically, Lactiplantibacillus plantarum strains confirmed to lack histidine decarboxylase (HDC) gene expression should be prioritized as starter cultures, and finished product biogenic amine content should be quantified and controlled in any clinical application
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