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The An 2019 clinical trial in Annals of Dermatology tested a crosslinked hyaluronic acid microneedle patch loaded with sh-Oligopeptide-1 and Acetyl Hexapeptide-8 against vehicle control in Korean women with peri-orbital wrinkles, and found significant reductions in wrinkle depth and improvements in skin elasticity over 8 weeks [37]
![Erythrocyte glutathione concentration ([GSH]), FSR, and absolute](https://www.researchgate.net/profile/Dominique-Darmaun-3/publication/8114549/figure/fig2/AS:281517835210752@1444130490313/Erythrocyte-glutathione-concentration-GSH-FSR-and-absolute-synthesis-rate-ASR-in.png)
