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Each component has been independently characterized in peer-reviewed preclinical research literature on PubMed

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However, because those types of SNPs are not currently reported in commercial tests, individuals may require either a trial-and-error approach by supplementing with one particular form of B 12 at a time, or they might simply use a supplement with a combination of all 3 naturally occurring forms of B 12 that are commercially available for a better chance of achieving faster clinical results