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These chronic active MS lesions may also harbor at their core (but not at their expanding edges) a perivascular cuff of CNS tissue-resident B and T cells (Machado-Santos et al., 2018

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No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate