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The analysis revealed that Day 30 represents the peak of functional maturity, marked by the highest expression of key-metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4), along with cholangiocyte-specific proteins and hepatic metabolic enzymes

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Importantly, this reduction in nicotinic receptor gene expression is associated with severen neurodegeneration and impaired hippocampus dependent learning in mice (Farhat et al., 2019)