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The mechanism by which amylin slows gastric emptying is still unknown, but evidence from animal studies suggests that amylin may influence the efferent activity of the vagus nerve via neurons in the brainstem
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Macrophages are differentiated monocytes that can be activated and polarized into different types by classical or bypass ligands, thereby mediating further targeting effects, and these have been shown to play a key role in immunity, inflammation, and oncology [32,33,34]
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