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The resulted mtDNA damage will lead to mitochondrial dysfunction by affecting respiration activity and metabolism
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GnT-IVa is missing the LHL insertion, which in GnT-II interacts with GlcNAcβ1-2Manα1-3Man, named as a “recognition arm,” of the acceptor N -glycan, suggesting the different acceptor recognition mode of GnT-IVa compared with that of GnT-II
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