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Since the presence of GPX4 U46C renders cells inherently sensitive to peroxide-induced ferroptosis, Gpx4 U46C animals showed a significantly shorter survival time after renal IRI compared to wildtype animals, accompanied by increases in serum creatinine and urea values, tubular damage scores and 4-HNE positivity [73]
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Hence, to understand the role of arsenic, it seems to be essential to precisely comprehend the importance of influx and transporter pathways
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