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The severity of symptoms associated with fibroid, average blood loss and HRQL were also significantly improved with the use of green tea extract as compared to placebo, with no adverse effects identified ( Catechol-O-methyl transferase (COMT) is an enzyme expressed at a higher level in leiomyoma as compared to the normal myometrium ( In vitro study showed that the ability of green tea extract in inhibiting the proliferation of leiomyoma cells is in part due to the potential of EGCG in reducing the expression of the COMT enzyme (Zhang et al., 2014)

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