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Taking into account the complexity of these multiple intra- and interconnections, the circadian clock emerges as a crucial regulator of key physiological processes and its misalignment as potential triggering factor and/or pathological outcome in several human diseases, such as cancer and inflammatory diseases

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Concomitantly, Reactive Oxygen Species (ROS), generated as a byproduct of the oxidative metabolism process, is a requisite secondary signaling factor in T cell immunity