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The accumulation of hypoxanthine, a biomarker of the RBC metabolic storage lesion and a predictor of PTR in stored human and murine RBCs, is observed not just in human RBCs, but also in other primates (macaques [153], baboons [154]) and mammals (e.g., mouse [155], rats [156], guinea pigs [157], cows, dogs, donkey and horses [158]), though at different rates as a function of species genotypes, suggesting a genetic regulation of this pathway—which is relevant for veterinary transfusion considerations [159]
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S-Acetyl Glutathione modifies the molecule at its sulfur-containing site, creating a protected form designed to improve stability while retaining the ability to contribute to intracellular glutathione pathways
