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The satiety produced by amylin analogues tends to reduce caloric intake without the extreme food aversion that sometimes occurs with high-dose GLP-1 agonists, which can lead to inadequate protein intake and subsequent muscle loss

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MAO-B inhibitors like selegiline in high dosage have been used in therapy-refractory depressions probably due to non-selective MAO effects (see review Laux, 1993)