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Octreoscan and NeoTect (tc-99m depreotide) are the only radiopeptide tracers on the market approved by the Food and Drug Administration [37, 38]

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however, their expression at the juxtaparanodes of myelinated axons is reduced in animal models of diabetes and in patient-derived samples 109 , suggesting that this adaptive mechanism to suppress hyperexcitability is lost in painful diabetic neuropathy