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Since its identification in the 1990s by the research group of Sikiric et al., it has become one of the most extensively studied peptides in tissue repair research, with published data spanning tendon healing, angiogenesis, nitric oxide regulation, and gastrointestinal cytoprotection

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Limitations This review provides an extensive overview of global epidemiological trends, underlying pathophysiological mechanisms, signaling networks, neuroprotective strategies, and clinical advancements in the management of ischemic stroke