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Common (reported in clinical and observational studies): Mild topical irritation or erythema, particularly in higher-concentration formulations or on sensitized skin Transient skin warmth or flushing at the application site Less common but reported: Signs consistent with copper excess (headache, nausea, abdominal discomfort) if used at higher concentrations or in combination with other copper-containing supplements

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This review aims to provide a scientific basis that can guide future research on the etiology and treatment of constipation