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Antiviral Potency : Antiviral potency is considered low for adefovir, intermediate for lamivudine, and high for entecavir, tenofovir alafenamide, and tenofovir DF.[4,8] Available data have shown that 68 to 90% of persons with chronic hepatitis B who are treated with entecavir, tenofovir alafenamide, or tenofovir DF will achieve undetectable plasma HBV DNA levels after 48 weeks of therapy.[4,9,10,11,12] For persons with high HBV viral levels, neither adefovir nor lamivudine would be an ideal choice compared with the newer agents, primarily because of their lower potency