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For some if not all matrix metalloproteinases (enzymes involved in the degradation of extracellular matrix components), activation occurs through sulfinic acid generation at Cys100 in the propeptide, also via initial oxidation to S-nitrosocysteine and/or Cys sulfenic acid (e.g., in rodent and human MMP-9 and MMP-7) [118–120]

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3.1 Clinical studies of ferroptosis in neurodegenerative diseases Human biospecimen analyses revealed elevated agrin expression, reduced levels of platelet-derived growth factor receptor beta (PDGFRβ), type IV collagen, and fibronectin, pronounced small artery atherosclerosis and venous collagen deposition, and a reduction in pericyte numbers in the brain tissue of AD patients