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Table 2 from Rationalization of the pKa Values of Alcohols and Thiols Using Atomic Charge Descriptors and Its Application to the Prediction of Amino Acid pKa's | Semantic Scholar

These results suggest that the genotype of the cancer is an important consideration and may affect whether NO exerts the desired anticancer effects or does the opposite

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Preclinical studies employ highly variable citrulline dosages, including dietary incorporation (0.6%-1%) ( in vitro concentrations (1–2 mM) ( 5.3 Efficacy evaluation Regarding outcomes, while current research effectively documents improvements in intermediate endpoints like sperm motility, mitochondrial membrane potential, and DNA fragmentation ( Current research on L-citrulline’s protective mechanisms remains largely confined to conventional biomarkers, such as OS markers (e.g., ROS, SOD) and mitochondrial function parameters (93)