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GRIN-related neurodevelopmental disorder (GRIN-NDD) refers to a spectrum disorder caused by de novo mutations in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes, which produce pathological variants that alter NMDA receptor activity - ranging from gain-of-function to loss-of-function, depending on the specific mutations

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10.3390/ijms241210200 Int J Mol Sci