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In RA pathogenesis, activated RA fibroblast-like synoviocytes (RA-FLSs) exhibit proliferative features similar to tumor cells and subsequently cause cartilage erosion, which will eventually lead to joint destruction ( It has been hypothesized that iron is excessively accumulated in the synovium of RA patients to perpetuate inflammation ( 2 Overview of ferroptosis Cell death is a fundamental physiological process in all aspects of life